Icatibant Acetate ( —— )

产品货号. M23545 CAS No. 138614-30-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Icatibant Acetate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Icatibant Acetate 是一种缓激肽 B2 受体拮抗剂，用于治疗遗传性血管性水肿。
产品描述

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
体外实验

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体内实验

Animal Model:Female mice of the CBA/J (H-2k) strain.Dosage:0.06, 0.3, or 1.5 mg/kg.Administration:Subcutaneous administration twice daily.Result:The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
同义词

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通路

GPCR/G Protein
靶点

Bradykinin Receptor
受体

bradykinin B2
研究领域

——
适应症

——

CAS Number

138614-30-9
分子量

1364.57
分子式

C61H93N19O15S
纯度

>98% (HPLC)
溶解度

DMSO:100 mg/mL?(73.28 mM;?Need ultrasonic)
SMILES

CC(=O)O.N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3cccs3)C(=O)N[C@@H](CO)C(=O)N4Cc5ccccc5C[C@@H]4C(=O)N6[C@H]7CCCC[C@H]7C[C@H]6C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
化学全称

——

1.Charignon D, et al. Expert Opin Pharmacother. 2012, 13(15):2233-47.

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